Thymic keratin76 shapes skin-specific central tolerance
M. Gelmetti, Inês M. Tomás, Roberta Ragazzini, Sara Campinoti, Megan S. F. Soon, M. Cautela, Matteo Vietri Rudan, Marina Torre, Nital Sumaria, Inês Saldanha, Diana Pereira, Norman Teik-Wei Yap, Mirjana Efremova, Zewen Kelvin Tuong, Fiona M. Watt, , Inês Sequeira
This study shows that keratin76 in the thymus is crucial for central tolerance to skin and oral mucosa antigens, as its loss leads to autoimmune responses.
bioRxiv · Aug 31, 2026 · PreprintImmunology