Megan S. F. Soon

Thymic keratin76 shapes skin-specific central tolerance

This study shows that keratin76 in the thymus is crucial for central tolerance to skin and oral mucosa antigens, as its loss leads to autoimmune responses.

Persistent circulating autoreactive PD1⁺TIGIT⁺ peripheral helper T cells reflect synovial lymphoid activity and poor response to conventional disease-modifying anti-rheumatic drugs in early rheumatoid arthritis

Circulating T-follicular helper and type I regulatory T cells have overlapping phenotypes in P. falciparum malaria and are maintained by parasite exposure.

The paper characterizes malaria-specific Tfh and Tr1 cells in a longitudinal cohort, finding overlapping phenotypes and showing their decline after transmission interruption.

Temporally overlapping mechanisms diversify clonal B cell responses in vivo.

Single-cell RNA and BCR sequencing of infected mouse spleens shows class switching overlaps clonal expansion, GC-seeding clones also form plasmablasts, and SHM proceeds at constant rate.

Comparison of CD4 T cell response in Plasmodium falciparum and vivax malaria

This study compares CD4 T cell responses to Plasmodium falciparum and P. vivax malaria, finding similar activation and proliferation but species-specific differences in peripheral Tfh cell subsets and IL-10 production.

Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.