Inês Sequeira

This study shows that keratin76 in the thymus is crucial for central tolerance to skin and oral mucosa antigens, as its loss leads to autoimmune responses.

The paper creates a multimodal atlas of human scalp tissue, revealing cell states, lineage organization, and disease-specific perturbations in hair loss conditions.

Human Developmental Cell Atlas integrates ~4.6 million cells/nuclei from 4-22 post-conception weeks into 454 refined cell types and maps 114 spatial niches across 6PCW whole-embryo sections.

This paper presents a single-cell and spatial proteotranscriptomic atlas of human oral tissues, identifying fibroblasts as key immunoregulatory hubs and revealing changes in disease states.

This paper develops a Swin Transformer-based model to predict kinase inhibitor mechanisms of action from Cell Painting data, achieving higher accuracy than traditional image-based profile methods.