Author

M. D. Betterton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 4 Research Focus:cell signaling & trafficking· 3 Approach:deep learning· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. Ansari· 3 shared Z. R. Gergely· 3 shared A. L. Crooks· 1 shared A. R. Lamson· 1 shared B. Zhou· 1 shared C. J. Edelmaier· 1 shared C. Pagan Medina· 1 shared C. S. Detweiler· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

S. Ansari

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment

S. C. Allgood, C.-C. Su, A. L. Crooks, C. T. Meyer, B. Zhou, M. D. Betterton, M. R. Barbachyn, E. W. Yu, C. S. Detweiler

This paper identifies and improves efflux pump modulators (EPMs) that inhibit bacterial growth in macrophages and enhance antibiotic potency under host-like conditions.

bioRxiv · Sep 20, 2023Microbiology

Quantifying yeast microtubules and spindles using the Toolkit for Automated Microtubule Tracking (TAMiT)

S. Ansari, Z. R. Gergely, P. Flynn, G. Li, J. K. Moore, M. D. Betterton

The paper introduces TAMiT, an automated tool for tracking fluorescent microtubules in yeast cells, showing it reliably detects and measures microtubule dynamics even at low signal-to-noise ratios.

bioRxiv · Feb 7, 2023 · PreprintCell Biology

Mechanical coupling with the nuclear envelope shapes the S. pombe mitotic spindle

M. A. Begley, C. Pagan Medina, T. Couture, P. Zareiesfandabadi, M. B. Rapp, M. Tirfe, S. LeBlanc, M. D. Betterton, M. W. Elting

This study shows that the mitotic spindle and nuclear envelope in S. pombe mechanically influence each other during closed mitosis, with spindle compression relieved by reducing nuclear envelope tension.

bioRxiv · Dec 28, 2022 · PreprintBiophysics

Kinesin-5/Cut7 moves bidirectionally on fission-yeast spindles with activity that increases in anaphase

Z. R. Gergely, M. H. Jones, S. Ansari, R. McIntosh, M. D. Betterton

This study shows that the kinesin-5 motor Cut7p moves bidirectionally on fission yeast spindles, with increased activity during anaphase B, and its localization is dependent on its motility.

bioRxiv · Aug 1, 2022Cell Biology

CyLaKS: the Cytoskeleton Lattice-based Kinetic Simulator

S. A. Fiorenza, M. D. Betterton, D. G. Steckhahn

CyLaKS simulates spatiotemporal dynamics of cytoskeletal filaments and motors, showing how factors like heterogeneity and crosslinker number affect filament behavior.

bioRxiv · Mar 31, 2021 · PreprintBiophysics

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

C. J. Edelmaier, A. R. Lamson, Z. R. Gergely, S. Ansari, R. Blackwell, J. R. McIntosh, M. A. Glaser, M. D. Betterton

This study develops a computational model of fission-yeast mitosis to analyze mechanisms of chromosome biorientation and bipolar spindle assembly.

bioRxiv · Oct 22, 2019Cell Biology

Bound-state diffusion due to binding to flexible polymers in a selective biofilter

L. E. Hough, M. D. Betterton, L. Maguire

The paper demonstrates bound-state diffusion in synthetic gels using protein fragments from the nuclear pore complex, showing quantitative agreement with theoretical predictions.

bioRxiv · Aug 15, 2019Biophysics