L. E. Hough

Aggregation of an FG nucleoporin under crowded conditions

This study examines how different crowding agents affect the aggregation of an FG nucleoporin peptide, revealing variations in kinetics and residue microenvironment.

Biophysical characterization of high-confidence, small human proteins

The paper characterizes biophysical properties of small human proteins, finding significant differences compared to larger proteins and providing insights for distinguishing functional from non-coding small open reading frames.

ParSe 2.0: A web application that enables proteome-scale searches for sequences that drive protein-mediated phase separation

ParSe 2.0 predicts protein regions that drive phase separation using sequence-based descriptors and is available as a web application.

Coiled-coil domains are sufficient to drive liquid-liquid phase separation of proteins in molecular models

This study shows coiled-coil domains can drive liquid-liquid phase separation in molecular models, with multimerization state playing a key role.

Intrinsically disordered regions that drive phase separation form a robustly distinct protein class

The paper identifies amino acid property scales that distinguish phase-separating intrinsically disordered regions from other protein regions and improves a predictor for these regions.

Beta Turn Propensity and a Model Polymer Scaling Exponent Identify Disordered Proteins that Phase Separate

The paper identifies disordered proteins that phase separate by analyzing their polymer scaling exponent and beta-turn propensity, introducing a new algorithm, ParSe.

C-terminal tail polyglycylation and polyglutamylation alter microtubule mechanical properties

This study investigates how polyglycylation and polyglutamylation of tubulin C-terminal tails affect microtubule stiffness and structure.

Bound-state diffusion due to binding to flexible polymers in a selective biofilter

The paper demonstrates bound-state diffusion in synthetic gels using protein fragments from the nuclear pore complex, showing quantitative agreement with theoretical predictions.