Author

M. D. Diers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. R. Webber· 2 shared B. S. Moriarity· 2 shared M. Choudhry· 2 shared M. J. Johnson· 2 shared R. S. McIvor· 2 shared T. Henley· 2 shared W. S. Lahr· 2 shared A. P. DeFeo· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

B. R. Webber

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cells

B. R. Webber, M. J. Johnson, N. S. Slipek, W. S. Lahr, A. P. DeFeo, J. G. Skeate, X. Qiu, B. Rathmann, M. D. Diers, B. Wick, T. Henley, M. Choudhry, R. S. McIvor, B. S. Moriarity

This paper describes a non-viral method for efficiently integrating large DNA into primary human T cells using CRISPR-Cas9 and homology-mediated end joining, achieving high functionality and anti-tumor activity.

bioRxiv · Nov 12, 2021 · PreprintBioengineering

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

D. C. Palmer, B. R. Webber, Y. Patel, M. J. Johnson, C. M. Kariya, W. S. Lahr, M. R. Parkhurst, J. J. Gartner, T. D. Prickett, F. J. Lowery, R. J. Kishton, D. Gurusamy, Z. Franco, S. K. Vodnala, M. D. Diers, , N. P. Restifo

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

bioRxiv · Sep 24, 2020Immunology