M. J. Johnson

Engineering Memory T Cells as a platform for Long-Term Enzyme Replacement Therapy in Lysosomal Storage Disorders

This study demonstrates that genetically engineered memory T cells can deliver enzyme replacement therapy for mucopolysaccharidosis type I, reducing GAG levels in multiple tissues for up to 22 weeks.

A novel method for improving the accuracy of MR-derived patient-specific vascular models using X-ray angiography

This paper introduces a method to enhance MR-derived vascular models using X-ray angiography, improving accuracy in stroke risk assessment for pediatric Moyamoya disease.

Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cells

This paper describes a non-viral method for efficiently integrating large DNA into primary human T cells using CRISPR-Cas9 and homology-mediated end joining, achieving high functionality and anti-tumor activity.

Genetic editing of CISH enhances T cell effector programs independently of immune checkpoint cell surface ligand expression

This study shows that genetic editing of CISH enhances T cell anti-tumor activity independently of PD-L1 expression, outperforming PD-1 and TIGIT disruption in certain contexts.

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

Computer vision to automatically assess infant neuromotor risk

This paper develops a computer vision method to assess infant neuromotor risk using video recordings and Bayesian Surprise calculations, showing that at-risk infants deviate more from healthy controls.