M. Gallagher-Jones

Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation

The paper shows that polarized mechanosensitive domains in endothelial cells mediate anti-inflammatory signaling under high shear stress.

Fragment-based ab initio phasing of peptidic nanocrystals by MicroED

This paper introduces a fragment-based method for de novo structure determination of peptidic nanocrystals using MicroED, enabling the solution of previously intractable structures.

APEX2 proximity proteomics resolves flagellum subdomains and identifies flagellum tip-specific proteins in Trypanosoma brucei

This paper uses APEX2 proximity proteomics to identify flagellum subdomain-specific proteins in Trypanosoma brucei, revealing tip-specific proteins involved in signal transduction.

Homochiral and racemic MicroED structures of a peptide from the ice nucleation protein InaZ

The paper determines homochiral and racemic structures of a peptide from InaZ using MicroED, revealing amyloid-like protofibrils with distinct chiral arrangements.

Analysis of global and site-specific radiation damage in cryo-EM

The paper analyzes radiation damage in cryo-EM using MicroED, finding similar damage dynamics to X-ray crystallography, including metal ion perturbation and disulfide bond breaking.