Author

M. D. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

D. A. Wohl· 3 shared D. M. Smith· 3 shared E. S. Daar· 3 shared J. J. Eron· 3 shared J. S. Currier· 3 shared K. W. Chew· 3 shared A. Heaps· 2 shared C. Moser· 2 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

D. A. Wohl

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback

C. H. Coelho, N. Bloom, S. I. Ramirez, U. M. Parikh, A. Heaps, S. F. Sieg, A. Greninger, J. Ritz, C. Moser, J. J. Eron, J. S. Currier, P. Klekotka, D. A. Wohl, E. S. Daar, J. Li, , Accelerating COVID-19 Therapeutic Interventions and Vaccines: 2/A5401 (ACTIV-2/A5401) Study Team

This study shows that SARS-CoV-2 mAb treatment shifts memory B cell epitope recognition, affecting their response to vaccination.

bioRxiv · Nov 21, 2023 · PreprintImmunology

Early antiviral CD4 and CD8 T cell responses and antibodies are associated with upper respiratory tract clearance of SARS-CoV-2

S. I. Ramirez, P. G. Lopez, F. Faraji, U. M. Parikh, A. Heaps, J. Ritz, C. Moser, J. J. Eron, D. A. Wohl, J. S. Currier, E. S. Daar, A. L. Greninger, P. Klekotka, A. Grifoni, D. Weiskopf, , ACTIV-2/A5401 Study Team

The paper examines early T cell and antibody responses in COVID-19 patients and finds they correlate with reduced SARS-CoV-2 viral RNA in the upper respiratory tract.

bioRxiv · Oct 25, 2023 · PreprintImmunology

Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody

T. Phan, C. Zitzmann, K. W. Chew, D. M. Smith, E. S. Daar, D. A. Wohl, J. J. Eron, J. S. Currier, M. D. Hughes, M. C. Choudhary, R. Deo, J. Z. Li, R. M. Ribeiro, R. Ke, A. S. Perelson

This paper models viral resistance emergence in SARS-CoV-2 treated with anti-spike monoclonal antibodies, showing that target cell replenishment mechanisms can explain high viral rebounds.

bioRxiv · Sep 14, 2023Immunology