Author

M. C. Choudhary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Organism:virus· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Z. Li· 4 shared A. Addetia· 1 shared A. Dauphin· 1 shared A. Ensser· 1 shared A. H. Tavares· 1 shared A. Herrmann· 1 shared A. J. Greaney· 1 shared A. K. O'Connell· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersMicrobiology

J. Z. Li

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody

T. Phan, C. Zitzmann, K. W. Chew, D. M. Smith, E. S. Daar, D. A. Wohl, J. J. Eron, J. S. Currier, M. D. Hughes, M. C. Choudhary, R. Deo, J. Z. Li, R. M. Ribeiro, R. Ke, A. S. Perelson

This paper models viral resistance emergence in SARS-CoV-2 treated with anti-spike monoclonal antibodies, showing that target cell replenishment mechanisms can explain high viral rebounds.

bioRxiv · Sep 14, 2023Immunology

S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness

L. Yurkovetskiy, S. Egri, C. Kurhade, M. A. Diaz-Salinas, J. A. Jaimes, T. Nyalile, X. Xie, M. C. Choudhary, A. Dauphin, J. Z. Li, J. B. Munro, P.-Y. Shi, K. Shen, J. Luban

This study shows that S:D614G and S:H655Y mutations enhance SARS-CoV-2 infectivity by stabilizing the Spike protein in an open RBD conformation, acting epistatically with the polybasic S1/S2 cleavage site.

bioRxiv · Mar 30, 2023 · PreprintMicrobiology

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

D.-Y. Chen, D. Kenney, C.-V. Chin, A. H. Tavares, N. Khan, H. L. Conway, G. Liu, M. C. Choudhary, H. P. Gertje, A. K. O'Connell, D. N. Kotton, A. Herrmann, A. Ensser, J. H. Connor, M. Bosmann, , M. Saeed

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

bioRxiv · Oct 13, 2022 · PreprintMicrobiology

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

T. N. Starr, A. J. Greaney, A. Addetia, W. H. Hannon, M. C. Choudhary, A. S. Dingens, J. Z. Li, J. D. Bloom

The paper maps viral mutations in SARS-CoV-2 that escape two therapeutic antibodies, identifying escape mutations present in circulating strains.

bioRxiv · Nov 30, 2020Microbiology