D. Weiskopf

Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans

This study identifies CHIKV-specific CD4+ T cell responses in chronic CHIKVD patients, showing stronger responses and Th17 enrichment compared to resolved infection.

Early antiviral CD4 and CD8 T cell responses and antibodies are associated with upper respiratory tract clearance of SARS-CoV-2

The paper examines early T cell and antibody responses in COVID-19 patients and finds they correlate with reduced SARS-CoV-2 viral RNA in the upper respiratory tract.

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

Long-term respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

This study shows that hybrid immunity from infection plus vaccination generates durable lung mucosal immunity, while peripheral vaccination alone does not.

Targets and cross-reactivity of human T cell recognition of Common Cold Coronaviruses

This study identifies T cell epitopes and cross-reactivity patterns across common cold coronaviruses, highlighting conservation and limitations in cross-reactivity among subgenera.

IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques

This study examines the roles of IFNγ and IL-10 in SARS-CoV-2 infection of rhesus macaques, finding IL-10 suppresses T cell expansion but promotes tissue-resident memory cell formation.

NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responses

This study shows NVX-CoV2373 vaccine induces CD4+ and CD8+ T cell responses, with CD4+ T cells correlating with neutralizing antibody titers.

Unaltered T cell responses to common antigens in individuals with Parkinson's disease

This study compares T cell responses to common antigens in Parkinson's disease patients and healthy controls, finding no significant differences in antigen-specific T cell activation or cytokine production.

Humoral and cellular immune memory to four COVID-19 vaccines

This study evaluates immune memory responses to four COVID-19 vaccines over six months, finding stable T and B cell memory but declining neutralizing antibodies with mRNA vaccines.

Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines

This study evaluates neutralizing activity against Omicron BA.1 and BA.2 variants elicited by various vaccines and finds that booster doses enhance neutralizing titers and breadth across all vaccine platforms.

Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period

The paper assesses immunological memory to Common Cold Coronaviruses over three years and finds sustained CD4+ T cell and antibody responses, suggesting stable memory rather than frequent reinfections.

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

This study shows that SARS-CoV-2 replication declines in the lungs before T cell responses, while innate immunity restricts viral replication in nasal and oral mucosa in rhesus macaques.

Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response

The paper analyzes the quality of SARS-CoV-2 specific T-cell response in relation to disease severity, immune memory, and heterologous response, finding distinct patterns in mild and severe infections and immune memory.

SARS-CoV-2 vaccination induces immunological memory able to cross-recognize variants from Alpha to Omicron

This study shows that SARS-CoV-2 vaccines induce T cell responses that cross-recognize variants from Alpha to Omicron, with high preservation of CD4+ and CD8+ T cell epitopes.

Distinguishing COVID-19 infection and vaccination history by T cell reactivity

This study develops a T cell-based method to distinguish between SARS-CoV-2 infection and vaccination by analyzing T cell reactivity to specific epitopes, achieving high classification accuracy across different groups.

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

Rapid induction of antigen-specific CD4+ T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

This study shows that mRNA vaccination rapidly induces antigen-specific CD4+ T cells, which coordinate humoral and cellular immune responses, with booster doses enhancing T cell responses in naive individuals.

Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.

The paper analyzes T cell responses to SARS-CoV-2 variants and finds minimal impact on CD4+ and CD8+ T cell reactivity in convalescents and vaccinees.

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

The paper identifies SARS-CoV-2 epitopes recognized by CD4+ and CD8+ T cells in COVID-19 patients and develops epitope megapools for their detection.

Immunological memory to SARS-CoV-2 assessed for up to eight months after infection

The paper assesses SARS-CoV-2 immune memory components over eight months post-infection, finding varying kinetics in antibodies, B cells, and T cells.

Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

This study shows baricitinib reduces lung inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques without affecting viral shedding or immune responses.

Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination.

This study identifies and characterizes CD4+ T cell epitopes specific to Shingrix vaccination, showing a shift in immunodominance from non-structural proteins to gE and mapping HLA restrictions for these epitopes.

A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells

This study analyzes single-cell transcriptomes of SARS-CoV-2 reactive CD4+ T cells in COVID-19 patients, finding differences in cell types and gene expression between severe and mild disease.

T cell responses induced by attenuated flavivirus vaccination are specific and show limited cross-reactivity with other flavivirus species.

This study shows that T cell responses to flavivirus vaccines are specific and have limited cross-reactivity with other flavivirus species.

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

This study examines how the time between Zika and dengue virus infections affects immune responses, finding that prior Zika exposure enhances antibody and T cell responses to dengue without increasing viremia.

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.

Immuno-proteomic interrogation of dengue infection reveals novel HLA haplotype-specific MHC-I antigens

This study identifies novel MHC-I antigens specific to dengue virus infection using an immuno-proteomics approach, revealing ligands associated with distinct HLA haplotypes and T-cell recognition.