Author

M. D. Stone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:DNA methylation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Palka· 2 shared C. R. Bagshaw· 2 shared J. Hentschel· 2 shared J. W. Parks· 2 shared L. I. Jansson· 2 shared A. P. Deshpande· 1 shared C. P. Lapointe· 1 shared J. Choi· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

C. Palka

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multiplexed single-molecule analysis of human telomerase synthesizing DNA

J. Hentschel, J. Choi, C. R. Bagshaw, C. P. Lapointe, J. Wang, L. I. Jansson, M. Badstubner, J. D. Puglisi, M. D. Stone

This paper develops a real-time single-molecule RNA sequencing method to visualize telomerase catalysis and structural dynamics at single-nucleotide resolution.

bioRxiv · Jun 25, 2021 · PreprintBiophysics

Single-molecule Mechanical Analysis of Strand Invasion in Human Telomere DNA

T. Chang, X. Long, S. Shastry, J. W. Parks, M. D. Stone

This study uses magnetic tweezers to form telomeric D-loops and shows that displaced DNA folds into G-quadruplexes, providing insight into telomere structure and potential therapeutic targets.

bioRxiv · Jun 22, 2021Biophysics

Folding heterogeneity in the essential human telomerase RNA three-way junction

C. Palka, N. M. Forino, J. Henstchel, R. Das, M. D. Stone

This study investigates the structural dynamics of the human telomerase RNA three-way junction, revealing that it adopts a heterogeneous ensemble of conformations and that a stable 3WJ is necessary but not sufficient for RNP assembly.

bioRxiv · Dec 14, 2019Biochemistry

Reevaluation of the RNA binding properties of the Tetrahymena thermophila telomerase reverse transcriptase N-terminal domain

C. Palka, A. P. Deshpande, M. D. Stone, K. Collins

The paper reevaluates the RNA binding properties of the Tetrahymena thermophila TERT TEN domain and finds that it binds RNAs based on length rather than sequence due to contamination in previous studies.

bioRxiv · May 10, 2019 · PreprintBiochemistry

Telomere DNA G-quadruplex folding within actively extending human telomerase

L. I. Jansson, J. W. Parks, J. Hentschel, T. R. Chang, R. Baral, C. R. Bagshaw, M. D. Stone

This study investigates how G-quadruplex (GQ) folding of nascent telomere DNA affects telomerase catalysis and dissociation kinetics.

bioRxiv · Oct 26, 2018Biochemistry