Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death
R. Avelar, A. Armstrong, G. Carvette, N. Puleo, R. Gupta, J. Colina, P. Joseph, A. Sobeck, C. O'Connor, A. Gandhi, M. Dziubinski, D. Ma, S. Waggoner, K. Zanotti, C. Nagel, , A. DiFeo
This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.
bioRxiv · Jun 10, 2022Cancer Biology