P. Joseph

Parallel on-chip micropipettes enabling quantitative multiplexed characterization of vesicle mechanics and cell aggregates rheology

This paper introduces a high-throughput method for quantitatively measuring mechanical properties of biological samples using parallel micropipettes.

Mechanical characterization of regenerating Hydra tissue spheres

This study characterizes the mechanical properties of Hydra vulgaris tissue spheres using microaspiration and simulations, revealing three distinct mechanical behaviors during regeneration.

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

SYS-Mut: Decoding the Functional Significance of Rare Somatic Mutations in Cancer

SYS-Mut identifies functional significance of rare somatic mutations in cancer by integrating multi-omic data, revealing lipidogenic networks as therapeutic targets in HNSC.

The EphB2-MYC Axis is a Major Determinant of Barrett's Pathobiology and a Therapeutic Vulnerability in Esophageal Cancer

This study identifies the EphB2-MYC axis as a key driver of Barrett's Esophagus progression to esophageal adenocarcinoma and a potential therapeutic target.

ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

Complete blood count with differential: An effective diagnostic for IBS subtype in the context of BMI?

The paper analyzes CBC-D data from a clinical cohort to identify potential biomarkers for IBS subtypes and BMI, finding significant associations but poor predictive performance.