Stiffness-dependent active wetting enables optimal collective cell durotaxis
M. E. Pallares, I. Pi-Jauma, I. C. Fortunato, V. Grazu, M. Gomez-Gonzalez, P. Roca-Cusachs, J. M. de la Fuente, R. Alert, R. Sunyer, J. Casademunt, X. Trepat
This study shows that cellular clusters migrate optimally on stiffness gradients by balancing active traction, contractility, and surface tension, based on their wetting properties.
bioRxiv · Jul 24, 2022 · PreprintBiophysics