M. F. Lythgoe

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

89Zr-oxine labelling and PET imaging shows lung delivery of a cell/gene cancer therapy

The paper demonstrates that 89Zr-oxine PET imaging can track MSCTRAIL cell therapy biodistribution in a lung cancer mouse model, showing lung delivery and viability.

Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice

This study demonstrates that ultrasound-guided renal artery injection can effectively deliver and retain a large proportion of stem cells in the kidney of mice for 3 days.

Combining optical imaging of cleared tissue with mathematical modelling to predict drug delivery and therapeutic response

The paper develops a computational framework to predict drug delivery and therapeutic response by integrating optical imaging and mathematical modeling in tumor tissue.

Investigating low-velocity fluid flow in tumours using convection-MRI

This study develops convection-MRI to investigate low-velocity fluid flow in tumors and shows it correlates with interstitial fluid pressure measurements in mouse models.

Non-invasive measurement of hepatic venous oxygen saturation (ShvO2) with quantitative susceptibility mapping in normal mouse liver and livers bearing colorectal metastases

This study uses quantitative susceptibility mapping (QSM) to non-invasively measure hepatic venous oxygen saturation in mice, showing significant differences in oxygen levels between healthy livers and those with colorectal metastases.