Author

P. Sweeney

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 3 Approach:statistical model· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:spatial domain detection· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. Walker-Samuel· 3 shared R. Shipley· 2 shared A. Crowe· 1 shared A. d'Esposito· 1 shared A. Desjardins· 1 shared A. Guy· 1 shared A. Kumar· 1 shared A. Markaki· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

S. Walker-Samuel

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Author profile →

4 papers

Recent·Most cited

Physics-informed deep generative learning for quantitative assessment of the retina

E. Brown, A. Guy, N. Holroyd, P. Sweeney, L. Gourmet, H. Coleman, C. Walsh, A. Markaki, R. Shipley, R. Rajendram, S. Walker-Samuel

This paper introduces a physics-informed GAN to generate realistic retinal blood vessel models, outperforming human labeling in segmentation and reconstruction.

bioRxiv · Jul 10, 2023Biophysics

Structure, dynamics, and inhibition of Staphylococcus aureus m1A22-tRNA methyltransferase

P. Sweeney, A. Crowe, A. Kumar, D. Raju, N. B. Krishna, E. Sutherland, C. J. Leo, G. Fisher, R. Lalitha, L. Muthuraj, G. Sigamani, V. Oehler, S. Synowsky, S. L. Shirran, T. M. Gloster, , R. G. da Silva

This study characterizes the structure, dynamics, and inhibition of Staphylococcus aureus TrmK, identifying a cryptic binding pocket for drug discovery.

bioRxiv · Dec 24, 2021 · PreprintBiochemistry

Combining optical imaging of cleared tissue with mathematical modelling to predict drug delivery and therapeutic response

A. d'Esposito, P. Sweeney, M. Ali, M. Saleh, R. Ramasawmy, T. A. Roberts, A. Desjardins, M. F. Lythgoe, R. B. Pedley, R. Shipley, S. Walker-Samuel

The paper develops a computational framework to predict drug delivery and therapeutic response by integrating optical imaging and mathematical modeling in tumor tissue.

bioRxiv · Nov 15, 2017Biophysics

Insights into cerebral haemodynamics and oxygenation utilising in vivo mural cell imaging and mathematical modelling

P. Sweeney, S. Walker-Samuel, R. J. Shipley

This study combines in vivo imaging and mathematical modeling to reveal new insights into cerebral blood flow regulation and oxygenation mechanisms.

bioRxiv · Oct 12, 2017Biophysics