Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
13 papers
Recent·Most cited
I. G. Wong, M. Paschini, J. Stark, A. B. Vazquez, V. Ya, A. L. Moye, S. M. Dang, M. F. Trovero, E. L. Thompson, S. Ahmed, F. N. Chaudhry, A. Shehaj, M. J. Rouhani, R. Bronson, S. M. Janes, , C. F. Kim
This study shows that airway injury triggers alveolar type 2 cell proliferation mediated by macrophages, revealing a myeloid-driven response in the lung.
bioRxiv · Apr 2, 2024Cell Biology
J. C. Orr, A. Laali, P. F. Durrenberger, K. A. Lazarus, M.-B. El Mdawar, S. M. Janes, R. E. Hynds
This paper develops lentiviral reporter constructs to quantitatively monitor airway epithelial cell differentiation using bioluminescence in vitro.
bioRxiv · Feb 9, 2024Cell Biology
F. Tommasini, T. Benoist, S. Shibuya, M. N. J. Woodall, E. Naldi, J. C. Orr, G. G. Giobbe, E. F. Maughan, R. E. Hynds, A. Gjinovci, J. C. Hutchinson, O. J. Arthurs, S. M. Janes, N. Elvassore, C. M. Smith, , P. De Coppi
This paper develops a bioreactor-based whole-organ lung model to study viral infections and demonstrates its use for testing antiviral drugs like Remdesivir.
bioRxiv · Feb 1, 2023Bioengineering
D. R. Pearce, A. U. Akarca, R. P. H. De Maeyer, E. Kostina, A. Huebner, M. Sivakumar, T. Karasaki, K. Shah, S. M. Janes, N. E. McGranahan, V. Reddy, A. Akbar, D. A. Moore, T. Marafioti, C. Swanton, R. E. Hynds
The paper identifies lymphoproliferative B cells in NSCLC PDX models and develops a tool for generating pathology overview figures.
bioRxiv · Jan 24, 2023Cancer Biology
R. E. Hynds, A. Huebner, D. R. Pearce, A. U. Akarca, D. A. Moore, S. Ward, K. H. C. Gowers, T. Karasaki, M. S. Hill, M. Al Bakir, G. A. Wilson, O. Pich, M. Sivakumar, A. Ben Aissa, E. Gronroos, , C. Swanton
This study examines how well PDX models capture intratumour heterogeneity in NSCLC, finding that most models originate from a single subclone but regional models can capture diversity.
bioRxiv · Jan 6, 2023Cancer Biology
J. L. Barnes, P. He, M. Yoshida, K. B. Worlock, R. G. H. Lindeboom, C. Suo, J. P. Pett, A. Wilbrey-Clark, E. Dann, L. Mamanova, L. Richardson, A. J. Oliver, A. L. Pennycuick, J. Allen-Hyttinen, I. T. Herczeg, , M. Z. Nikolic
The paper profiles lung immune cells during development using scRNAseq and identifies IL-1β's role in driving epithelial progenitor differentiation.
bioRxiv · Dec 13, 2022Immunology
J. Choi, Y. J. Jang, C. Dabrowska, E. Iich, K. Evans, H. Hall, S. M. Janes, B. D. Simons, B.-K. Koo, J. Kim, J.-H. Lee
The paper identifies an IL-1β-Notch-Fosl2 axis that regulates differentiation plasticity of airway progenitors during alveolar regeneration.
bioRxiv · Jun 19, 2021Cell Biology
F. R. Millar, A. Pennycuick, M. Muir, A. Quintanilla, P. Hari, E. Freyer, P. Gautier, A. Meynert, V. H. Teixeira, J. Connelly, W. A. Wallace, A. H. Sims, M. C. Frame, L. Boulter, S. M. Janes, , J. C. Acosta
This study identifies TLR2 as a tumor suppressor in early-stage lung cancer, showing its role in immune surveillance and tumor growth reduction through synthetic agonist administration.
bioRxiv · Jun 4, 2021 · PreprintCancer Biology
Y. Ishii, K. K. Kolluri, A. Pennycuick, E. Nigro, D. Alrifai, E. Borg, M. Falzon, K. Shah, N. Kumar, S. M. Janes
This study shows BAP1 and YY1 suppress TRAIL receptor expression in MPM, making them potential targets to enhance TRAIL therapy.
bioRxiv · Aug 31, 2020Cancer Biology
E. F. Maughan, R. E. Hynds, A. Pennycuick, E. Nigro, K. H. C. Gowers, C. Denais, S. Gomez-Lopez, K. A. Lazarus, J. C. Orr, D. R. Pearce, S. E. Clarke, D. D. H. Lee, M. N. J. Woodall, T. Masonou, K.-M. Case, , S. M. Janes
The paper compares airway epithelial cells from children and adults, finding intrinsic differences in transcriptional profiles and regenerative capacity.
bioRxiv · Apr 20, 2020Cell Biology
D. D. H. Lee, D. Cardinale, E. Nigro, C. R. Butler, A. Rutman, M. R. Fassad, R. A. Hirst, D. Moulding, A. Agrotis, E. Forsythe, D. Peckham, E. Robson, C. M. Smith, S. Somavarapu, P. L. Beales, , C. O'Callaghan
The paper develops a high-content screening method using differentiated respiratory epithelium from PCD patients to evaluate readthrough therapies for rare respiratory diseases.
bioRxiv · Feb 28, 2020 · PreprintCell Biology
A. Pennycuick, V. H. Teixeira, K. AbdulJabbar, S. E. A. Raza, T. Lund, A. Akarca, R. Rosenthal, C. P. Pipinikas, H. Lee-Six, D. P. Chandrasekharan, R. E. Hynds, K. H. C. Gowers, J. Y. Henry, C. Denais, M. Falzon, , S. M. Janes
The paper investigates immune surveillance in pre-invasive squamous cell lung cancer, finding that regressive lesions have more immune infiltration and distinct molecular profiles compared to progressive lesions.
bioRxiv · Nov 10, 2019Cancer Biology
P. S. Patrick, K. K. Kolluri, M. Zaw Thin, A. Edwards, E. K. Sage, T. Sanderson, B. D. Weil, J. C. Dickson, M. F. Lythgoe, M. Lowdell, S. M. Janes, T. L. Kalber
The paper demonstrates that 89Zr-oxine PET imaging can track MSCTRAIL cell therapy biodistribution in a lung cancer mouse model, showing lung delivery and viability.
bioRxiv · Aug 22, 2019 · PreprintCell Biology