Loss And Gain Of Function Experiments Implicate TMEM18 As A Mediator Of The Strong Association Between Genetic Variants At Human Chromosome 2p25.3 And Obesity
R. Larder, M. F. M. Sim, P. Gulati, R. Antrobus, Y. C. L. Tung, D. Rimmington, E. Ayuso, J. Polex-Wolf, B. Y. H. Lam, C. Dias, D. W. Logan, S. Virtue, F. Bosch, G. S. H. Yeo, V. Saudek, , A. P. Coll
The paper identifies TMEM18 as a mediator of genetic variants at 2p25.3 associated with obesity through loss and gain of function experiments in mice.
bioRxiv · Mar 31, 2017Physiology