Author

A. P. Coll

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

D. Rimmington· 3 shared S. O'Rahilly· 3 shared G. S. H. Yeo· 2 shared S. Virtue· 2 shared Y. C. L. Tung· 2 shared A. A. Voors· 1 shared A. Al-Hadithi· 1 shared A. Melvin· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersPhysiology

D. Rimmington

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia

M. Ferrer, N. Mourikis, E. E. Davidson, S. O. Kleeman, M. Zaccaria, J. Habel, R. Rubino, T. R. Flint, C. M. Connell, M. Lukey, E. P. White, A. P. Coll, A. R. Venkitaraman, T. Janowitz

This study shows that a ketogenic diet slows tumor growth but accelerates cachexia and shortens survival in IL-6-driven cancer models by inducing ferroptosis and corticosterone deficiency.

bioRxiv · Feb 17, 2023Cancer Biology

GDF15 antagonism limits severe heart failure and prevents cardiac cachexia in mice

M. Takaoka, J. A. Tadross, A. Al-Hadithi, R. Villena-Gutierrez, J. Tromp, S. Absar, M. Au, J. Harrison, A. P. Coll, S. J. Marciniak, D. Rimmington, E. Oliver, B. Ibanez, A. A. Voors, S. O'Rahilly, , J. C. Goodall

This study shows that blocking GDF15 reduces severe heart failure and cardiac cachexia in mice by preventing weight loss and slowing disease progression.

bioRxiv · Sep 6, 2022Pathology

GDF15 and the beneficial actions of metformin in pre-diabetes

A. P. Coll, M. Chen, P. Taskar, D. Rimmington, S. Patel, J. Tadross, I. Cimino, M. Yang, P. Welsh, S. Virtue, D. A. Goldspink, E. Miedzybrodzka, Y. C. L. Tung, S. Rodriguez-Cuenca, R. A. Tomaz, , S. O'Rahilly

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.

bioRxiv · Jun 21, 2019Physiology

Loss And Gain Of Function Experiments Implicate TMEM18 As A Mediator Of The Strong Association Between Genetic Variants At Human Chromosome 2p25.3 And Obesity

R. Larder, M. F. M. Sim, P. Gulati, R. Antrobus, Y. C. L. Tung, D. Rimmington, E. Ayuso, J. Polex-Wolf, B. Y. H. Lam, C. Dias, D. W. Logan, S. Virtue, F. Bosch, G. S. H. Yeo, V. Saudek, , A. P. Coll

The paper identifies TMEM18 as a mediator of genetic variants at 2p25.3 associated with obesity through loss and gain of function experiments in mice.

bioRxiv · Mar 31, 2017Physiology