Author

S. Virtue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:metabolism & bioenergetics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Vidal-Puig· 3 shared D. B. Savage· 3 shared S. O'Rahilly· 3 shared S. Patel· 3 shared A. Alvarez-Guaita· 2 shared A. Haider· 2 shared A. P. Coll· 2 shared D. Rimmington· 2 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCell Biology

A. Vidal-Puig

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Limited oxygen availability in standard cell culture alters metabolism and function in terminally-differentiated cells

J. Tan, S. Virtue, D. M. Norris, O. J. Conway, M. Yang, C. Gribben, F. Lutgu, J. R. Krycer, R. J. Mills, I. Kamzolas, C. Pereira, M. Dale, A. S. Shun-Shion, H. J. Baird, J. A. Horscroft, , D. J. Fazakerley

This study shows that increasing oxygen levels in cell culture improves metabolic function and responsiveness in terminally differentiated cells like adipocytes and hepatocytes.

bioRxiv · Nov 29, 2022 · PreprintCell Biology

A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

J. P. Mann, X. Duan, A. Alvarez-Guaita, A. Haider, I. Luijten, M. Page, S. Patel, F. Scurria, M. Protasoni, L. C. Tabara, S. Virtue, S. I. O'Rahilly, M. Armstrong, J. Prudent, R. K. Semple, D. B. Savage

This study uses a mouse model to show that a MFN2 mutation causes adipose-specific mitochondrial stress and reduced leptin secretion, linking mitochondrial dysfunction to metabolic disease.

bioRxiv · Sep 20, 2022Cell Biology

Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.

S. Patel, A. Haider, A. Alvarez-Guaita, G. Bidault, J. S. El-Sayed Moustafa, E. Guiu-Jurado, J. A. Tadross, J. Warner, J. Harrison, S. Virtue, F. Scurria, I. Zvetkova, M. Blüher, K. S. Small, S. O'Rahilly, D. B. Savage

This study shows that GDF15 and FGF21, secreted by the liver in obese mice, reduce hepatic steatosis and insulin resistance when both are active.

bioRxiv · Jun 8, 2022 · PreprintPhysiology

GDF15 and the beneficial actions of metformin in pre-diabetes

A. P. Coll, M. Chen, P. Taskar, D. Rimmington, S. Patel, J. Tadross, I. Cimino, M. Yang, P. Welsh, S. Virtue, D. A. Goldspink, E. Miedzybrodzka, Y. C. L. Tung, S. Rodriguez-Cuenca, R. A. Tomaz, , S. O'Rahilly

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.

bioRxiv · Jun 21, 2019Physiology

Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

K. Petkevicius, S. Virtue, G. Bidault, B. Jenkins, C. Cubuk, C. Morgantini, M. Aouadi, J. Dopazo, M. Serlie, A. Koulman, A. Vidal-Puig

This study shows that increased phosphatidylcholine synthesis in macrophages during obesity drives inflammation in adipose tissue, contributing to insulin resistance.

bioRxiv · May 8, 2019Cell Biology

Loss And Gain Of Function Experiments Implicate TMEM18 As A Mediator Of The Strong Association Between Genetic Variants At Human Chromosome 2p25.3 And Obesity

R. Larder, M. F. M. Sim, P. Gulati, R. Antrobus, Y. C. L. Tung, D. Rimmington, E. Ayuso, J. Polex-Wolf, B. Y. H. Lam, C. Dias, D. W. Logan, S. Virtue, F. Bosch, G. S. H. Yeo, V. Saudek, , A. P. Coll

The paper identifies TMEM18 as a mediator of genetic variants at 2p25.3 associated with obesity through loss and gain of function experiments in mice.

bioRxiv · Mar 31, 2017Physiology