Author

M. G. Frattini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. H. Shih· 1 shared A. M. Intlekofer· 1 shared A. Tosolini· 1 shared A. Viale· 1 shared A. Zehir· 1 shared B. Fan· 1 shared B. Wu· 1 shared C. Famulare· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. H. Shih

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2 papers

Recent·Most cited

Antiproliferative Activity of Cephalotaxus Esters: Overcoming Chemoresistance in Cancer Therapy

V. Yong-Gonzalez, C. Radu, P. A. Calder, D. Shum, M. G. Frattini, H. Djaballah

This study evaluates the antiproliferative effects of HHT and its derivatives against cancer cells, finding that they overcome MDR1-mediated resistance in some cell lines but are effective against primary leukemia cells.

bioRxiv · Nov 6, 2023 · PreprintPharmacology & Toxicology

Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition

J. J. Harding, M. A. Lowery, A. H. Shih, J. M. Schvartzman, S. Hou, C. Famulare, M. Patel, M. Roshal, R. K. G. Do, A. Zehir, D. You, S. D. Selcuklu, A. Viale, M. S. Tallman, D. M. Hyman, , A. M. Intlekofer

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.

bioRxiv · Aug 1, 2018Cancer Biology