Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease
S. Scarneo, A. Smith, J. Favret, R. O'connell, J. Pickeral, K. Yang, G. Ferrari, D. Loiselle, P. Hughes, M. Kulkarni, M. Gargesha, B. Scott, D. Roy, B. Haynes, J. Kweik, T. Haystead
This study identifies eHsp90 as a marker of T cell activation, showing its upregulation in autoimmune diseases and demonstrating the efficacy of an inhibitor in delaying disease progression.
bioRxiv · Jun 6, 2021 · PreprintPharmacology & Toxicology