Author

P. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

T. Haystead· 2 shared A. Brown· 1 shared A. Smith· 1 shared B. Haynes· 1 shared B. R. Pears· 1 shared B. Scott· 1 shared D. Loiselle· 1 shared D. Roy· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPharmacology & Toxicology

T. Haystead

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Early Neolithic forest farming at Seven Springs, Martlesham, Suffolk inferred from sedaDNA and pollen

S. M. Hudson, S. J. Allen, I. G. Alsos, J. Curl, P. D. Heintzman, P. Hughes, L. Gardiner, L. Lloyd-Smith, B. R. Pears, R. Scaife, K. R. Stoof-Leichsenring, A. Brown

This study uses sedaDNA and pollen analysis to show Early Neolithic agro-pastoralists used wetland springs for pastoral and ritual activities in Suffolk, UK.

bioRxiv · Oct 11, 2023 · PreprintEcology

Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

S. Scarneo, A. Smith, J. Favret, R. O'connell, J. Pickeral, K. Yang, G. Ferrari, D. Loiselle, P. Hughes, M. Kulkarni, M. Gargesha, B. Scott, D. Roy, B. Haynes, J. Kweik, T. Haystead

This study identifies eHsp90 as a marker of T cell activation, showing its upregulation in autoimmune diseases and demonstrating the efficacy of an inhibitor in delaying disease progression.

bioRxiv · Jun 6, 2021 · PreprintPharmacology & Toxicology

Oral Hsp90 inhibitor, SNX-5422, attenuates SARS-CoV-2 replication and dampens inflammation in airway cells.

R. Goswami, V. S. Russell, J. J. Tu, P. Hughes, F. Kelly, S. N. Langel, J. Steppe, S. M. Palmer, T. Haystead, M. Blasi, S. R. Permar

This study shows that the Hsp90 inhibitor SNX-5422 reduces SARS-CoV-2 replication and inflammation in airway cells, suggesting its potential as an early therapeutic.

bioRxiv · Feb 23, 2021Microbiology