G. Ferrari

Chromosome-level genome assembly of Greenland scurvy-grass (Cochlearia groenlandica) reveals extensive centromeric satellite arrays

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.

Tracing 600 years of long-distance Atlantic cod trade in medieval and post-medieval Oslo using stable isotopes and ancient DNA

This study uses ancient DNA and stable isotopes to trace the origins of Atlantic cod traded in Oslo from the 11th to 17th centuries, revealing long-distance trade networks.

Five millennia of mitochondrial introgression in Atlantic bluefin tuna identified using ancient DNA

This study uses ancient DNA to show that mitochondrial introgression in Atlantic bluefin tuna has persisted for five millennia without significant anthropogenic impact.

Real-Time Structural Biology of DNA and DNA-Protein Complexes on an Optical Microscope

This study develops a method to study DNA and DNA-protein interactions with high spatial and temporal resolution using graphene and energy transfer.

Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions

This study shows non-neutralizing SARS-CoV-2 antibodies protect mice from severe disease via Fc-mediated effector functions, reducing viral load and lung damage.

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes

This study designs engineered immunogens targeting conserved coronavirus epitopes to elicit broad-spectrum antibodies, showing protection in mice against live virus challenge.

Ancient DNA evidence for the ecological globalisation of cod fishing in medieval and post-medieval Europe

This study uses ancient DNA to trace the origins of Atlantic cod specimens from medieval to post-medieval Europe, showing shifts from local to distant sources over time.

Food resources drive rodent population demography mediated by seasonality and inter-specific competition

This study investigates how food resources, seasonality, and competition shape rodent population dynamics across different latitudes.

Inhibition of advanced glycation end product formation and serum protein infiltration in bioprosthetic heart valve leaflets: Investigations of anti-glycation agents.

This study investigates anti-AGE agents' effects on AGE and serum protein infiltration in bioprosthetic heart valves using in vitro and in vivo models, finding that PYR significantly inhibits AGE and serum albumin accumulation.

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

RAGE antagonist peptide mitigates AGE-mediated endothelial hyperpermeability and accumulation of glycoxidation products in human ascending aortas and in a murine model of aortic aneurysm

Vaccine-induced, high magnitude HIV Env-specific antibodies with Fc-mediated effector functions are insufficient to protect infant rhesus macaques against oral SHIV infection

This study tests a vaccine regimen in infant rhesus macaques, finding that Env-specific antibodies with Fc effector functions do not prevent oral SHIV infection.

Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain

The paper identifies an antibody from a clinical trial that binds a different HIV-1 Env domain than VRC01-class antibodies and shows that epitope switching requires specific CDR changes.

A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1

The paper identifies a genetic shift in an HIV-1 transmitted/founder virus that leads to broader antibody responses by altering the V2 domain structure.

Expression of extracellular Hsp90 is a molecular signature of T cell activation, providing a means to image and target T Cell activation in autoimmune disease

This study identifies eHsp90 as a marker of T cell activation, showing its upregulation in autoimmune diseases and demonstrating the efficacy of an inhibitor in delaying disease progression.

DLL4 and PDGF-BB regulate migration of human iPSC-derived skeletal myogenic progenitors

This study shows that DLL4 and PDGF-BB enhance migration of hiPSC-derived myogenic progenitors without affecting proliferation, supporting their use in muscle therapies.

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

This study compares the immunogenicity of mRNA-LNP vaccines to protein vaccines in nonhuman primates, finding comparable or superior HIV-1 antibody responses.

Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity

The paper isolates antibodies that bind HLA-E-Leader peptide complexes and enhance NK cell cytotoxicity in both mice and humans.

Deterioration of Glutaraldehyde Crosslinked Heterograft Biomaterials due to Advanced Glycation End Product Formation and Serum Albumin Infiltration

This study investigates how AGE formation and serum albumin infiltration degrade glutaraldehyde crosslinked biomaterials, leading to structural and mechanical deterioration in bioprosthetic heart valves.

The preservation of ancient DNA in archaeological fish bone

This study investigates DNA preservation in archaeological fish bones, finding high endogenous DNA levels and highlighting the role of bone remodeling in DNA preservation across vertebrates.

Inhibition and down regulation of the serotonin transporter contribute to the progression of degenerative mitral regurgitation

This study investigates how inhibition and downregulation of the serotonin transporter (SLC6A4) contribute to the progression of degenerative mitral regurgitation through enhanced HTR2B signaling.

Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves

This study shows glycation and serum albumin infiltration contribute to structural degeneration of bioprosthetic heart valves through mechanisms observed in both clinical samples and in vitro models.

Mitral valve leaflet response to ischemic mitral regurgitation: From gene expression to tissue remodeling

This study investigates mitral valve remodeling after myocardial infarction, identifying changes in gene expression, tissue mechanics, and immune cell recruitment.

Boosting with ALVAC-HIV and AIDSVAX B/E enhances Env constant region 1 and 2 antibody-dependent cellular cytotoxicity

The paper shows that boosting RV144 vaccine recipients with ALVAC-HIV and AIDSVAX B/E increases C1C2-specific antibody-dependent cellular cytotoxicity breadth and potency.

Single cell analysis of quiescent HIV infection reveals host transcriptional profiles that regulate proviral latency

This study uses single-cell methods to analyze HIV latency, finding that host transcriptional profiles correlate with proviral activity levels in infected cells.

Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys.

This study shows that a tri-mAb cocktail of HIV envelope-specific antibodies reduces SHIV acquisition and viral loads in infant rhesus monkeys.