Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir
M. Götte, C. J. Gordon, H. W. Lee, E. P. Tchesnokov, J. K. Perry, J. Y. Feng, J. P. Bilello, D. P. Porter
This study investigates how remdesivir's antiviral activity varies across RNA viruses by analyzing its incorporation and inhibition mechanisms in different polymerases.
bioRxiv · Oct 14, 2021Biochemistry