Author

H. W. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Microbiology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. J. Gordon· 2 shared D. P. Porter· 2 shared E. P. Tchesnokov· 2 shared J. K. Perry· 2 shared A. Abzhanov· 1 shared A. J. Pruijssers· 1 shared A. N. Beckett· 1 shared A. S. George· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

C. J. Gordon

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs

B. Lee, J. Park, A. Voshall, E. Maury, Y. Kang, Y. J. Kim, J.-Y. Lee, H.-R. Shim, H.-J. Kim, J.-W. Lee, M.-H. Jung, S.-C. Kim, H. B. K. Chu, D.-W. Kim, M. Kim, , E. A. Lee

The paper identifies cancer-specific transposon-fusion RNAs across 34 cancer types and finds they are associated with tumor suppressors and oncogenes, and can activate T-cells.

bioRxiv · Oct 16, 2023 · PreprintCancer Biology

A high-content screen identified ingenol-3-angelate as an enhancer of B7-H3-CAR T cell activity by increasing B7-H3 protein expression on the target cell surface via protein kinase C alpha activation

H. W. Lee, C. O'Reilly, A. N. Beckett, D. G. Currier, T. Chen, C. DeRenzo

The paper identifies ingenol-3-angelate as a drug that enhances B7-H3-CAR T cell activity by increasing B7-H3 protein expression on target cells through protein kinase C alpha activation.

bioRxiv · May 26, 2023 · PreprintCancer Biology

Beclin1-Deficient Adipocytes Promote Tumor Progression by YAP/TAZ-dependent Adipocyte Transformation

Y. Song, H. Na, S. E. Lee, T. Nam, Y. M. Kim, Y. Ji, Y. Jin, J.-H. Park, S. C. Cho, D. Hwang, S.-J. Ha, H. W. Park, J. B. Kim, H. W. Lee, J. Moon

This study shows that Beclin1-deficient adipocytes promote tumor progression via YAP/TAZ signaling, and inhibiting this pathway reduces tumor growth in mice.

bioRxiv · May 25, 2023 · PreprintBiochemistry

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

L. J. Stevens, A. J. Pruijssers, H. W. Lee, C. J. Gordon, E. P. Tchesnokov, J. Gribble, A. S. George, T. M. Hughes, X. Lu, J. Li, J. K. Perry, D. P. Porter, T. Cihlar, T. P. Sheahan, R. S. Baric, , M. R. Denison

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

bioRxiv · Jan 25, 2022 · PreprintMicrobiology

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

M. Götte, C. J. Gordon, H. W. Lee, E. P. Tchesnokov, J. K. Perry, J. Y. Feng, J. P. Bilello, D. P. Porter

This study investigates how remdesivir's antiviral activity varies across RNA viruses by analyzing its incorporation and inhibition mechanisms in different polymerases.

bioRxiv · Oct 14, 2021Biochemistry

6',6'-Difluoro-aristeromycin is a potent inhibitor of MERS-coronavirus replication

N. S. S. Ogando, J. Zevenhoven-Dobbe, D. Jarhad, S. K. Tripathi, H. W. Lee, L. S. Jeong, E. J. Snijder, C. C. Posthuma

This paper shows that 6',6'-difluoro-aristeromycin inhibits MERS-CoV replication but is cytotoxic and needs improvement for broader antiviral use.

bioRxiv · May 20, 2021 · PreprintMicrobiology

Evolutionary and ontogenetic changes of the anatomical organization and modularity in the skull of archosaurs

H. W. Lee, B. Esteve-Altava, A. Abzhanov

The paper compares anatomical organization and modularity in the skulls of archosaurs, finding differences between birds and non-avian dinosaurs, and ontogenetic changes in alligators and birds.

bioRxiv · Feb 21, 2020Evolutionary Biology