Author

E. P. Tchesnokov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

C. J. Gordon· 2 shared D. P. Porter· 2 shared H. W. Lee· 2 shared J. K. Perry· 2 shared A. J. Pruijssers· 1 shared A. S. George· 1 shared J. Gribble· 1 shared J. Li· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

C. J. Gordon

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintJan 25, 2022

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

L. J. Stevens, A. J. Pruijssers, H. W. Lee…·M. R. Denison

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

DOI 10.1101/2022.01.25.477724

viruswhole-genome sequencing

𝕏 PostBluesky

BiochemistrybioRxivOct 14, 2021

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

M. Götte, C. J. Gordon, H. W. Lee…·D. P. Porter

This study investigates how remdesivir's antiviral activity varies across RNA viruses by analyzing its incorporation and inhibition mechanisms in different polymerases.

DOI 10.1016/j.jbc.2021.101529

experimental assayhost-pathogen & immune response

𝕏 PostBluesky