Author

C. J. Gordon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:virus· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

E. P. Tchesnokov· 3 shared J. K. Perry· 3 shared D. P. Porter· 2 shared H. W. Lee· 2 shared J. P. Bilello· 2 shared J. Y. Feng· 2 shared M. Gotte· 2 shared A. J. Pruijssers· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

E. P. Tchesnokov

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3 papers

Recent·Most cited

Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

C. J. Gordon, S. M. Walker, E. P. Tchesnokov, D. Kocincova, J. Pitts, D. S. Siegel, J. K. Perry, J. Y. Feng, J. P. Bilello, M. Gotte

This study investigates how a 4'-cyano modified nucleotide analog inhibits RNA polymerases of respiratory viruses, showing varying efficiency across different viral species.

bioRxiv · Apr 22, 2024Biochemistry

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

L. J. Stevens, A. J. Pruijssers, H. W. Lee, C. J. Gordon, E. P. Tchesnokov, J. Gribble, A. S. George, T. M. Hughes, X. Lu, J. Li, J. K. Perry, D. P. Porter, T. Cihlar, T. P. Sheahan, R. S. Baric, , M. R. Denison

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

bioRxiv · Jan 25, 2022 · PreprintMicrobiology

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

M. Götte, C. J. Gordon, H. W. Lee, E. P. Tchesnokov, J. K. Perry, J. Y. Feng, J. P. Bilello, D. P. Porter

This study investigates how remdesivir's antiviral activity varies across RNA viruses by analyzing its incorporation and inhibition mechanisms in different polymerases.

bioRxiv · Oct 14, 2021Biochemistry