M. Godin

Targeting extracellular vesicle delivery to the lungs by microgel encapsulation

This study encapsulates extracellular vesicles in microgels to enhance their targeted delivery to the lungs, showing prolonged retention and increased uptake by lung cells.

Mechanotransduction of strain regulates an invasive phenotype in newly transformed epithelial cells

This study shows that mechanical stretch promotes an invasive phenotype in transformed epithelial cells by altering actin dynamics and Rho-ROCK pathway activity.

Time dependent stress relaxation and recovery in mechanically strained 3D microtissues

This study measures time-dependent stress relaxation and recovery in 3D microtissues under mechanical strain, finding stretched exponential behavior and a linear relationship between residual elasticity and stress relaxation.

Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch

This study investigates how 3D microtissues maintain mechanical homeostasis under dynamic stretch by remodeling their cytoskeleton, showing strain softening and recovery without fluidization.

Mechanical stretch sustains myofibroblast phenotype and function in microtissues through latent TGF-β1 activation

This study shows mechanical stretch maintains myofibroblast activation through latent TGF-β1 activation in microtissues, promoting fibrosis progression.

Time dependence of cellular responses to dynamic and complex strain fields

This study examines how fibroblasts respond to dynamic strain fields over time, showing decreasing reorientation to strain direction and increasing alignment to strain gradient direction.

A vacuum-actuated microtissue stretcher for long-term exposure to oscillatory strain within a 3D matrix

The paper introduces a microtissue stretcher device to study cellular responses to mechanical strain in 3D environments, showing reproducible strain delivery and increased F-actin expression under cyclic strain.