N-glycosylation engineering in chimeric antigen receptor T cells enhances anti-tumor activity
E. De Bousser, N. Festjens, E. Plets, L. Meuris, L. Vuylsteke, D. Fijalkowska, A. Van Hecke, E. Wyseure, M. Goossens, L. De Pryck, S. Van den Bosch, S. De Munter, B. Vandekerckhove, N. Callewaert
This study shows that removing N-glycan modifications in CAR T cells improves their anti-tumor activity against solid tumors and lymphomas.
bioRxiv · Jan 23, 2023 · PreprintImmunology