B. Vandekerckhove

N-glycosylation engineering in chimeric antigen receptor T cells enhances anti-tumor activity

This study shows that removing N-glycan modifications in CAR T cells improves their anti-tumor activity against solid tumors and lymphomas.

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

The paper shows that knocking out CD70 in CD70-specific nanoCAR T cells improves their functionality in vivo by preventing antigen-induced exhaustion.

Immunopeptidomics-based design of highly effective mRNA vaccine formulations against Listeria monocytogenes

The paper identifies Listeria monocytogenes epitopes using immunopeptidomics and shows that mRNA vaccines encoding these antigens induce strong immune responses and protection in mice.

Single-cell profiling identifies a spectrum of human unconventional intraepithelial T lineage cells

The paper identifies a spectrum of human unconventional intraepithelial T lineage cells using single-cell RNA sequencing and defines their phenotypic and transcriptomic features.

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

This study shows that RUNX2 promotes human NK cell generation and tissue residency through IL-2Rβ induction, with implications for cancer therapy.

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.