Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
Y. Xu, S. Spear, Y. Ma, M. P. Lorentzen, M. Gruet, F. McKinney, Y. Xu, C. Wickremesinghe, M. Shepherd, I. McNeish, H. C. Keun, A. Nijhuis
This study shows that combining RBM39 degraders with PARP inhibitors improves PARP inhibitor response in ovarian cancer, regardless of BRCA1/2 status.
bioRxiv · Jan 18, 2023Cancer Biology