Author

A. Nijhuis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

H. C. Keun· 2 shared A. Benito· 1 shared A. Montoya· 1 shared A. Sikka· 1 shared B. Martins da Costa· 1 shared C. Eckold· 1 shared C. Wickremesinghe· 1 shared D. Carling· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

H. C. Keun

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2 papers

Recent·Most cited

Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma

Y. Xu, S. Spear, Y. Ma, M. P. Lorentzen, M. Gruet, F. McKinney, Y. Xu, C. Wickremesinghe, M. Shepherd, I. McNeish, H. C. Keun, A. Nijhuis

This study shows that combining RBM39 degraders with PARP inhibitors improves PARP inhibitor response in ovarian cancer, regardless of BRCA1/2 status.

bioRxiv · Jan 18, 2023Cancer Biology

Indisulam targets RNA splicing and metabolism to serve as a novel therapeutic strategy for high-risk neuroblastoma

A. Nijhuis, A. Sikka, O. Yogev, L. Herendi, C. Eckold, G. Valbuena, Y. Liu, E. Kouloura, E. Poon, B. Martins da Costa, A. Benito, H. Kramer, A. Montoya, D. Carling, E. J. Want, , H. C. Keun

This study shows that indisulam, a sulphonamide, targets RNA splicing and metabolism to inhibit neuroblastoma growth and achieve complete tumor remission in preclinical models.

bioRxiv · Dec 18, 2020Cancer Biology