Author

M. Shepherd

Primary ORCID profile (0000-0001-8616-963X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

M. ShepherdiD1 paper · Natural England

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Nijhuis· 1 shared A. R. Mehdipour· 1 shared A. S. MacDonald· 1 shared C. Wickremesinghe· 1 shared D. Bald· 1 shared D. Conn· 1 shared D. Thomson· 1 shared D. Wu· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Nijhuis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics.

E. L. Houlder, S. Gago, G. Vere, D. Conn, S. Khan, D. Thomson, M. Shepherd, R. Lebedinec, G. D. Brown, M. Bromley, A. S. MacDonald, P. C. Cook

This study identifies a specific stage of Aspergillus fumigatus spore development that activates dendritic cells to trigger allergic airway inflammation and shows antifungal drugs can reduce this process.

Journal of Allergy and Clinical Immunology · Mar 1, 2025Peer-reviewedImmunology

Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma

Y. Xu, S. Spear, Y. Ma, M. P. Lorentzen, M. Gruet, F. McKinney, Y. Xu, C. Wickremesinghe, M. Shepherd, I. McNeish, H. C. Keun, A. Nijhuis

This study shows that combining RBM39 degraders with PARP inhibitors improves PARP inhibitor response in ovarian cancer, regardless of BRCA1/2 status.

bioRxiv · Jan 18, 2023Cancer Biology

Dissecting the conformational complexity and flipping mechanism of a prokaryotic heme transporter

D. Wu, A. R. Mehdipour, F. Finke, H. G. Goojani, R. R. Groh, T. N. Grund, T. M. Reichhart, R. Zimmermann, S. Welsch, D. Bald, M. Shepherd, G. Hummer, S. Safarian

The paper identifies CydDC as a heme flippase essential for cytochrome bd maturation, revealing its conformational mechanism through cryo-EM and molecular dynamics.

bioRxiv · Apr 7, 2022 · PreprintMicrobiology