TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection
S. N. Amrun, J. J. Tan, N. Y. Rickett, J. A. Cox, B. Lee, M. J. Griffiths, T. Solomon, D. Perera, M. H. Ooi, J. A. Hiscox, L. F. Ng
The paper investigates EV71 infection in human cells, identifies TREM-1 activation as a key driver of severe disease, and shows its role in inflammation and viral load.
bioRxiv · Jun 27, 2019Immunology