Author

J. J. Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

B. Lee· 2 shared L. F. Ng· 2 shared A. Ghosh· 1 shared C. Y. Lee· 1 shared C. Zhao· 1 shared D. J. Hodson· 1 shared D. Lee· 1 shared D. Matthews· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

B. Lee

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

14-3-3ζ constrains insulin secretion by regulating mitochondrial function in pancreatic β-cells

Y. Mugabo, C. Zhao, J. J. Tan, A. Ghosh, S. A. Campbell, E. Fadzeyeva, F. Pare, S. S. Pan, M. Galipeau, J. Ast, J. Broichhagen, D. J. Hodson, E. E. Mulvihill, S. Petropoulos, G. E. Lim

This study shows that 14-3-3ζ regulates insulin secretion in pancreatic β-cells by enhancing mitochondrial function and ATP synthesis, with implications for diabetes.

bioRxiv · Oct 17, 2021Physiology

TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection

S. N. Amrun, J. J. Tan, N. Y. Rickett, J. A. Cox, B. Lee, M. J. Griffiths, T. Solomon, D. Perera, M. H. Ooi, J. A. Hiscox, L. F. Ng

The paper investigates EV71 infection in human cells, identifies TREM-1 activation as a key driver of severe disease, and shows its role in inflammation and viral load.

bioRxiv · Jun 27, 2019Immunology

Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK-cell activity

F. M. Lum, D. Lee, T.-K. Chua, J. J. Tan, C. Y. Lee, X. Liu, Y. Fang, B. Lee, W.-X. Yee, N. Rickett, P.-Y. Chia, V. Lim, Y.-S. Leo, D. Matthews, J. Hiscox, L. F. Ng

This study investigates how ZIKV infection affects monocyte and NK-cell activity through transcriptomic and immunoproteomic analyses, revealing counterbalancing effects on immune responses.

bioRxiv · Dec 5, 2017Immunology