Author

T. Solomon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 2 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:metagenomics· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. Ruan· 2 shared D. Levy· 2 shared D. Motabar· 2 shared D. T. Gallagher· 2 shared E. J. Choi· 2 shared J. W. Harmon· 2 shared M. J. Griffiths· 2 shared P. N. Bryan· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

B. Ruan

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism

D. Levy, S. N. Abadchi, N. Shababi, M. R. Ravari, N. H. Pirolli, C. Bergeron, A. Obiorah, F. Mokhtari-Esbuie, S. Gheshlaghi, J. M. Abraham, I. M. Smith, E. Powsner, T. Solomon, J. W. Harmon, S. M. Jay

This study shows that extracellular vesicles from undifferentiated iPSCs outperform those from iMSCs in promoting wound healing in diabetic mice through anti-inflammatory effects.

bioRxiv · Mar 19, 2023Bioengineering

Design and characterization of a protein fold switching network

B. Ruan, Y. He, Y. Chen, E. J. Choi, Y. Chen, D. Motabar, T. Solomon, R. Simmerman, T. Kauffman, D. T. Gallagher, J. P. Orban, P. N. Bryan

The paper designs and characterizes a protein fold switching network where single amino acid substitutions can switch fold and function in proteins.

bioRxiv · Oct 26, 2022Biochemistry

The Impact of Storage Condition and Duration on Function of Native and Cargo-Loaded Mesenchymal Stromal Cell Extracellular Vesicles

D. Levy, A. Jeyaram, L. J. Born, K.-H. Chang, S. Nourmohammadi Abadchi, A. Ting Wei Hsu, T. Solomon, A. Aranda, S. Stewart, X. He, J. W. Harmon, S. M. Jay

This study evaluates how storage temperature, duration, and lyophilization affect the bioactivity and cargo retention of mesenchymal stromal cell extracellular vesicles.

bioRxiv · Jun 14, 2022Bioengineering

Rules for designing protein fold switches and their implications for the folding code

Y. Chen, Y. He, B. Ruan, E. J. Choi, Y. Chen, D. Motabar, T. Solomon, R. Simmerman, T. Kauffman, D. T. Gallagher, J. Orban, P. N. BRYAN

The paper designs protein fold switches between three common small folds and identifies rules for engineering dimorphic sequences that can populate multiple folds.

bioRxiv · May 18, 2021 · PreprintBiophysics

A systematic evaluation of IgM and IgG antibody assay accuracy in diagnosing acute Zika Virus infection in Brazil; lessons relevant to emerging infections

R. Medialdea-Carrera, F. Lowen Levy Chalhoub, P. Castanha, P. Carvalho Sequeira, P. Brasil, L. L. Lewis Ximenez, L. Turtle, T. Solomon, A. M. Bispo de Filippis, D. W. Brown, M. Griffiths

This study evaluates the accuracy of IgM and IgG antibody assays for diagnosing acute Zika Virus infection in Brazil, finding that IgG assays outperformed IgM ones and highlighting the need for careful evaluation in populations with co-circulating viruses.

bioRxiv · Nov 25, 2020Microbiology

Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection.

C. Goh, T. Golubchik, M. A. Ansari, M. de Cesare, A. Trebes, I. Elliott, D. Bonsall, P. Piazza, A. Brown, H. Slawinski, N. Martin, S. Defres, M. J. Griffiths, J. E. Bray, M. C. Maiden, , R. Bowden

Castanet, a targeted metagenomic sequencing method, improves pathogen detection in clinical samples by combining sensitivity with cost-effectiveness and broad organism coverage.

bioRxiv · Jul 28, 2019 · PreprintMicrobiology

TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection

S. N. Amrun, J. J. Tan, N. Y. Rickett, J. A. Cox, B. Lee, M. J. Griffiths, T. Solomon, D. Perera, M. H. Ooi, J. A. Hiscox, L. F. Ng

The paper investigates EV71 infection in human cells, identifies TREM-1 activation as a key driver of severe disease, and shows its role in inflammation and viral load.

bioRxiv · Jun 27, 2019Immunology

Complete assembly of a dengue virus type 3 genome from a recent genotype III clade by metagenomic sequencing of serum

C. Pattabiraman, M. Dias, S. Siddappa, M. Gowda, A. Shet, D. Smith, B. Muehlemann, K. Tamma, T. Solomon, T. Jones, S. Krishna

This study assembles a complete dengue virus type 3 genome from serum using metagenomic sequencing and identifies co-circulating Japanese encephalitis virus sequences in febrile patients.

bioRxiv · Oct 19, 2017Microbiology