Author

S. N. Amrun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1

Frequent Co-Authors

L. Renia· 5 shared B. Lee· 4 shared G. Carissimo· 4 shared R. S.-L. Chee· 4 shared Y.-S. Leo· 4 shared B. E. Young· 3 shared C. M. Poh· 3 shared C. Y.-P. Lee· 3 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

L. Renia

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

J. Lim, G. Carissimo, Y.-H. Chan, S.-W. Fong, W. W. Lee, S.-Y. Tan, D. C. Lye, B. E. Young, L. Renia, L. Fong-Poh NG, O. Rotzschke, K. J. Puan, L. W. Wang, K. W. W. Teng, C. Y. Loh, , B. Lee

The paper identifies immune signatures associated with COVID-19 severity and temporality, revealing distinct patterns and providing tools for data analysis.

bioRxiv · Feb 10, 2021 · PreprintImmunology

Neutralizing antibodies from early cases of SARS-CoV-2 infection offer cross-protection against the SARS-CoV-2 D614G variant.

C. Y.-P. Lee, S. N. Amrun, R. S.-L. Chee, Y. S. Goh, T. M. Mak, S. Octavia, N. Yeo, Z. W. Chang, M. Z. Tay, A. Torres, G. Carissimo, C. M. Poh, S.-W. Fong, B. Wang, S. Lee, , L. F. P. Ng

This study shows that antibodies from early SARS-CoV-2 infections neutralize both the original and D614G variants, though neutralizing capacity decreases over time.

bioRxiv · Oct 8, 2020 · PreprintImmunology

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19

G. Carissimo, W. Xu, I. Kwok, M. Y. Abdad, Y. H. Chan, S. W. Fong, K. J. Puan, C. Y. P. Lee, N. K.-W. Yeo, S. N. Amrun, R. S.-L. Chee, W. How, S. Chan, E. B. Fan, A. Andiappan, , L. F. Ng

The paper identifies an immature neutrophil-to-VD2 T-cell ratio as a prognostic marker for severe COVID-19 using flow cytometry data.

bioRxiv · Jun 11, 2020Immunology

Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein

C. M. Poh, G. Carissimo, W. Bei, S. N. Amrun, C. Y.-P. Lee, R. S.-L. Chee, N. K.-W. Yeo, W.-H. Lee, Y.-S. Leo, M. I.-C. Chen, S.-Y. Tan, L. Y. A. Chai, S. Kalimuddin, S.-Y. Thien, B. E. Young, , L. F. Ng

The paper identifies two immunodominant linear epitopes on the SARS-CoV-2 spike protein that are targets of potent neutralizing antibodies in convalescent patient sera.

bioRxiv · Mar 30, 2020Immunology

Trimester-specific Zika virus infection affects placental responses in women

F. M. Lum, V. Narang, S. Hue, C. Jie, N. McGovern, R. Rajarethinam, J. Tan, S. N. Amrun, Y. H. Chan, C. Y. P. Lee, T. K. Chua, W. X. Yee, N. K. W. Yeo, T. C. Tan, L. Xuan, , L. Ng

This study examines how ZIKV infection during different pregnancy trimesters affects placental immune and transcriptomic responses, identifying unique molecular changes associated with early infection.

bioRxiv · Aug 6, 2019 · PreprintImmunology

TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection

S. N. Amrun, J. J. Tan, N. Y. Rickett, J. A. Cox, B. Lee, M. J. Griffiths, T. Solomon, D. Perera, M. H. Ooi, J. A. Hiscox, L. F. Ng

The paper investigates EV71 infection in human cells, identifies TREM-1 activation as a key driver of severe disease, and shows its role in inflammation and viral load.

bioRxiv · Jun 27, 2019Immunology

Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients

S. N. Amrun, W.-X. Yee, F. Abu Bakar, B. Lee, Y.-W. Kam, F.-M. Lum, J. J. L. Tan, V. W. X. Lim, W. Watthanaworawit, C. Ling, F. Nosten, L. Renia, Y.-S. Leo, L. F. P. Ng

The paper identifies differential linear B-cell epitopes to distinguish Zika and Dengue virus infections, showing high sensitivity and specificity in patient samples.

bioRxiv · May 16, 2019Immunology