L. F. Ng

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice

This study shows Gas6 promotes ZIKV replication and severity in humans and mice, linking it to neurological complications and congenital malformations.

Inhibition of mTOR decreases insoluble protein burden by reducing translation in C. elegans

This study shows that inhibiting mTOR reduces insoluble protein accumulation and extends lifespan in C. elegans by decreasing translation.

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19

The paper identifies an immature neutrophil-to-VD2 T-cell ratio as a prognostic marker for severe COVID-19 using flow cytometry data.

Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein

The paper identifies two immunodominant linear epitopes on the SARS-CoV-2 spike protein that are targets of potent neutralizing antibodies in convalescent patient sera.

TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection

The paper investigates EV71 infection in human cells, identifies TREM-1 activation as a key driver of severe disease, and shows its role in inflammation and viral load.

Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK-cell activity

This study investigates how ZIKV infection affects monocyte and NK-cell activity through transcriptomic and immunoproteomic analyses, revealing counterbalancing effects on immune responses.

Doubling healthy lifespan using drug synergies

This paper shows that combining drugs targeting multiple ageing pathways in C. elegans can double lifespan and improve healthspan, with potential for human applications.