Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine
J. Durgan, A. H. Lystad, K. Sloan, S. R. Carlsson, M. I. Wilson, E. Marcassa, R. Ulferts, J. Webster, A. F. Lopez-Clavijo, M. J. Wakelam, R. Beale, A. Simonsen, D. Oxley, O. Florey
This study shows that during non-canonical autophagy, ATG8 proteins are conjugated to phosphatidylserine instead of phosphatidylethanolamine, revealing a distinct lipidation mechanism.
bioRxiv · May 14, 2020Cell Biology