A. H. Lystad

Lysosome repair by ER-mediated cholesterol transfer

The paper identifies an ER-mediated cholesterol transfer mechanism for lysosome repair independent of ESCRTs, involving PI4K2A and OSBP.

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

This study identifies GAK and PRKCD as positive regulators of PRKN-independent mitophagy through genetic screening and functional analysis in vitro and in vivo.

The Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy

This study shows that Vibrio cholerae toxin MakA induces noncanonical autophagy, which inhibits canonical autophagy and immune responses like IL-1β secretion.

Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

This study shows that during non-canonical autophagy, ATG8 proteins are conjugated to phosphatidylserine instead of phosphatidylethanolamine, revealing a distinct lipidation mechanism.

TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease

The paper shows TBK1 phosphorylates LC3C and GABARAP-L2, preventing their removal by ATG4 and ensuring proper autophagosome formation.