Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
R. Beale, A. P. Bertolin, B. Canal, J. F. Diffley, L. S. Drury, M. Howell, J. Milligan, V. Posse, R. Ulferts, F. Weissmann, M. Wu, J. Zeng
This study screens a chemical library to identify SARS-CoV-2 RdRp inhibitors, finding three novel compounds and confirming suramin-like compounds as inhibitors.
bioRxiv · Apr 7, 2021Biochemistry
C. Basier, R. Beale, G. Bineva-Todd, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, R. Fujisawa, M. Howell, D. Joshi, K. Labib, C. T. Lim, J. Milligan, H. Nagaraj, N. O'Reilly, , T. U. Zeisner
This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.
bioRxiv · Apr 7, 2021Biochemistry
C. Basier, S. Basu, R. Beale, A. P. Bertolin, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, A. W. McClure, J. Milligan, E. Roberts, , J. Zeng
This study identifies patulin and aurintricarboxylic acid as inhibitors of SARS-CoV-2 nsp14 exoribonuclease, showing antiviral activity in cell culture.
bioRxiv · Apr 7, 2021Biochemistry
L. A. Armstrong, R. Beale, G. Bineva-Todd, B. Canal, J. F. Diffley, L. S. Drury, M. Howell, Y. Kulathu, K. Labib, C. T. Lim, J. Milligan, N. O'Reilly, E. Ozono, K. W. Tan, R. Ulferts, , J. Zeng
This study identifies two small molecule inhibitors of SARS-CoV-2 Nsp3 PLpro that inhibit viral replication in cell culture.
bioRxiv · Apr 7, 2021Biochemistry
R. Beale, A. P. Bertolin, B. Canal, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, A. W. McClure, R. Ulferts, F. Weissmann, M. Wu, J. Zeng
This study screens for small molecule inhibitors of SARS-CoV-2 nsp15 endoribonuclease and identifies NSC95397 as an in vitro inhibitor, though its antiviral efficacy remains to be determined.
bioRxiv · Apr 7, 2021Biochemistry
R. Beale, A. P. Bertolin, A. Borg, B. Canal, J. F. Diffley, L. S. Drury, R. Harvey, M. Howell, S. Hussain, S. Kjaer, J. McCauley, L. McCoy, J. Milligan, V. Posse, C. Roustan, , J. Zeng
This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.
bioRxiv · Apr 7, 2021Biochemistry
C. Basier, S. Basu, R. Beale, B. Canal, V. H. Cowling, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, C. T. Lim, T. Mak, A. W. McClure, , T. U. Zeisner
This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.
bioRxiv · Apr 7, 2021Bioengineering
R. Ulferts, E. Marcassa, L. Timimi, L. C. Lee, A. Daley, B. Montaner, S. D. Turner, O. Florey, J. K. Baillie, R. Beale
The paper uses a subtractive CRISPR screen to identify factors involved in non-canonical LC3 lipidation, revealing distinct roles for ATG4D and the RALGAP complex in different contexts.
bioRxiv · Nov 18, 2020 · PreprintCell Biology
J. Durgan, A. H. Lystad, K. Sloan, S. R. Carlsson, M. I. Wilson, E. Marcassa, R. Ulferts, J. Webster, A. F. Lopez-Clavijo, M. J. Wakelam, R. Beale, A. Simonsen, D. Oxley, O. Florey
This study shows that during non-canonical autophagy, ATG8 proteins are conjugated to phosphatidylserine instead of phosphatidylethanolamine, revealing a distinct lipidation mechanism.
bioRxiv · May 14, 2020Cell Biology
K. W. Ng, N. Faulkner, G. Cornish, A. Rosa, R. Harvey, S. Hussain, R. Ulferts, C. Earl, A. Wrobel, D. Benton, C. Roustan, W. Bolland, R. Thompson, A. Agua-Doce, P. Hobson, , Mc
The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.
bioRxiv · May 14, 2020Immunology