Author

M. J. C. Long

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Organism:zebrafish· 2 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. R. Poganik· 3 shared Y. Aye· 3 shared A. Van Hall-Beauvais· 2 shared K.-T. Huang· 2 shared S. Parvez· 2 shared Y. Zhao· 2 shared B. Miller· 1 shared H.-Y. Lin· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

J. R. Poganik

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Author profile →

3 papers

Recent·Most cited

Z-REX uncovers a bifurcation in function of Keap1 paralogs

A. Van Hall-Beauvais, J. R. Poganik, K.-T. Huang, S. Parvez, Y. Zhao, H.-Y. Lin, X. Liu, M. J. C. Long, Y. Aye

The paper identifies divergent electrophile-signaling behaviors between zebrafish Keap1 paralogs using Z-REX, showing zKeap1b promotes Nrf2 signaling while zKeap1a inhibits it.

bioRxiv · Oct 10, 2022Pharmacology & Toxicology

Z-REX: Shepherding Reactive Electrophiles to Specific Proteins Expressed either Tissue-Specifically or Ubiquitously, and Recording the Resultant Functional Electrophile-Induced Redox Responses in Larval Fish

K.-T. Huang, J. R. Poganik, S. Parvez, S. Raja, B. Miller, M. J. C. Long, J. R. Fetcho, Y. Aye

This paper adapts a redox targeting tool for use in zebrafish embryos to study protein-specific electrophile-induced redox responses.

bioRxiv · Oct 6, 2022Biochemistry

The mRNA-binding protein HuR is a kinetically-privileged electrophile sensor

J. R. Poganik, A. Van Hall-Beauvais, M. J. C. Long, M. T. Disare, Y. Zhao, Y. Aye

This study identifies HuR as a kinetically-privileged sensor of the electrophile HNE, showing its role in regulating Nrf2-driven antioxidant responses through cysteine C13.

bioRxiv · Apr 7, 2020Biochemistry