Author

A. Van Hall-Beauvais

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

J. R. Poganik· 2 shared M. J. C. Long· 2 shared Y. Aye· 2 shared Y. Zhao· 2 shared A. Marchand· 1 shared A. Petruzzella· 1 shared A. Scheck· 1 shared A. Teslenko· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

J. R. Poganik

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Z-REX uncovers a bifurcation in function of Keap1 paralogs

A. Van Hall-Beauvais, J. R. Poganik, K.-T. Huang, S. Parvez, Y. Zhao, H.-Y. Lin, X. Liu, M. J. C. Long, Y. Aye

The paper identifies divergent electrophile-signaling behaviors between zebrafish Keap1 paralogs using Z-REX, showing zKeap1b promotes Nrf2 signaling while zKeap1a inhibits it.

bioRxiv · Oct 10, 2022Pharmacology & Toxicology

De novo design of site-specific protein interactions with learned surface fingerprints

P. Gainza, S. Wehrle, A. Van Hall-Beauvais, A. Marchand, A. Scheck, Z. Harteveld, D. Ni, S. Tan, F. Sverrisson, C. Goverde, P. Turelli, C. Raclot, A. Teslenko, M. Pacesa, S. Rosset, , B. E. Correia

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

bioRxiv · Jun 16, 2022 · PreprintBioengineering

The mRNA-binding protein HuR is a kinetically-privileged electrophile sensor

J. R. Poganik, A. Van Hall-Beauvais, M. J. C. Long, M. T. Disare, Y. Zhao, Y. Aye

This study identifies HuR as a kinetically-privileged sensor of the electrophile HNE, showing its role in regulating Nrf2-driven antioxidant responses through cysteine C13.

bioRxiv · Apr 7, 2020Biochemistry