Author

M. J. Cowley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. Wong· 3 shared A. Russell· 2 shared D. Cultrone· 2 shared D. Zahra· 2 shared J. B. Ziegler· 2 shared J. Warren· 2 shared M. E. Craig· 2 shared M. E. Dinger· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

M. Wong

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

C. Mayoh, A. Gifford, R. Terry, L. M. Lau, M. Wong, P. Rao, T. Shai-Hee, F. Saletta, D.-A. Khuong-Quang, V. Qin, M. Mateos, D. Meyran, K. E. Miller, A. Yuksel, E. V. Mould, , P. G Ekert

The paper develops a 15-gene immune signature to identify T-cell infiltration in high-risk paediatric cancers, finding up to 31% of such cancers have infiltrating T-cells.

bioRxiv · Sep 16, 2022 · PreprintCancer Biology

Environmental and genetic disease modifiers of haploinsufficiency of A20

N. N. Zammit, P. Gray, O. M. Siggs, J. Y. Yap, A. Russell, D. Cultrone, J. Warren, S. N. Walters, R. T. Brink, D. Zahra, D. L. Burnett, V. Gayevskiy, A. E. Minoche, J. B. Ziegler, M. E. Craig, , S. T. Grey

The paper identifies genetic and environmental modifiers that exacerbate autoinflammatory disease caused by A20 haploinsufficiency in humans.

bioRxiv · Mar 19, 2022 · PreprintImmunology

Unscrambling cancer genomes via integrated analysis of structural variation and copy number

C. Shale, J. Baber, D. Cameron, M. Wong, M. J. Cowley, A. T. Papenfuss, E. Cuppen, P. Priestley

This paper introduces LINX, a tool for analyzing structural variation and copy number alterations in cancer genomes, revealing novel insights into oncogenic fusions and inactivation events.

bioRxiv · Dec 3, 2020Cancer Biology

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

N. W. Zammit, O. M. Siggs, P. Gray, K. Horikawa, S. R. Daley, D. B. Langley, D. Cultrone, E. K. Malle, S. N. Walters, J. E. Villanueva, J. Warren, A. Russell, M. J. Cowley, V. Gayevskiy, M. E. Dinger, , M. E. Craig

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

bioRxiv · Mar 27, 2019 · PreprintImmunology