K. E. Miller

Cellular taxonomy of the preleukemic bone marrow niche of acute myeloid leukemia

The paper identifies changes in the bone marrow microenvironment during preleukemic stages of AML, including an expanded CD55+ fibroblast population that supports preleukemic stem cells over normal HSCs.

The fission yeast cell size control system integrates pathways measuring cell surface area, volume, and time

This paper identifies how fission yeast switch between surface area and volume-based cell size control based on ploidy and describes the roles of Cdc25 and Cdc13 in this system.

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

The paper develops a 15-gene immune signature to identify T-cell infiltration in high-risk paediatric cancers, finding up to 31% of such cancers have infiltrating T-cells.

Single-cell RNA Sequencing Reveals Immunosuppressive Myeloid Cell Diversity and Restricted Cytotoxic Effector Cell Trafficking and Activation During Malignant Progression in Glioma

This study uses single-cell RNA sequencing to analyze immune cell changes during glioma progression, identifying immunosuppressive myeloid cell subsets and potential therapeutic targets.

Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division

This study identifies Arf6 as an anchor for Cdr2 nodes at the cell cortex, essential for surface area-based size control in fission yeast.

Sequestration of the exocytic SNARE Psy1 into multiprotein nodes reinforces polarized morphogenesis in fission yeast

The paper shows that Psy1, a SNARE protein, is sequestered in Skb1-Slf1 nodes at non-growing cell sides in fission yeast, restricting exocytosis to growth sites and maintaining cell morphology.

A Critical Role of Hepatic GABA in The Metabolic Dysfunction and Hyperphagia of Obesity

This study shows that inhibiting hepatic GABA production in obese mice reduces hyperinsulinemia, improves glucose tolerance, and decreases food intake, suggesting a role for hepatic GABA in obesity-related metabolic dysfunction.

Hepatocyte Membrane Potential Regulates Serum Insulin and Insulin Sensitivity by Altering Hepatic GABA Release

This study identifies GABA as a novel hepatokine dysregulated in obesity, showing that hepatic GABA release affects serum insulin and insulin sensitivity.

Temporal regulation of cell polarity via the interaction of the Ras GTPase Rsr1 and the scaffold protein Bem1

The paper investigates how Rsr1, a Ras GTPase, interacts with Bem1 to regulate cell polarity in budding yeast, showing that Rsr1's GDP-bound state is crucial for spatial cue-directed polarization.

The contribution of mitochondrial metagenomics to largescale data mining and phylogenetic analysis of Coleoptera

This study uses mitochondrial metagenomics and bulk sequencing to assemble a large phylogenetic tree of Coleoptera, showing congruence with Linnaean taxonomy but limited resolution for basal nodes.