Author

D. B. Langley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Christ· 3 shared A. G. Stewart· 2 shared A. Kelleher· 2 shared H. Lenthall· 2 shared J. Jackson· 2 shared J. Y. Henry· 2 shared M. Sobti· 2 shared O. Mazigi· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

D. Christ

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

R. Rouet, J. Y. Henry, M. D. Johansen, M. Sobti, H. Balachandran, D. B. Langley, G. Walker, H. Lenthall, J. Jackson, S. Ubiparipovic, O. Mazigi, P. Schofield, D. L. Burnett, S. H. J. Brown, M. Martinello, , D. Christ

This paper isolates broadly neutralizing SARS-CoV-2 antibodies from convalescent patients and shows they neutralize emerging variants more effectively than existing monoclonal antibodies.

bioRxiv · Oct 19, 2022Immunology

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

R. Rouet, O. Mazigi, G. J. Walker, D. B. Langley, M. Sobti, P. Schofield, H. Lenthall, J. Jackson, S. Ubiparipovic, J. Y. Henry, A. Abayasingam, D. Burnett, A. Kelleher, R. Brink, R. A. Bull, , D. Christ

This paper explores antibody maturation strategies to enhance the neutralization of SARS-CoV-2 using SARS-CoV-1 antibodies, finding that some variants show potent neutralization with IC50 of 160 ng/ml.

bioRxiv · Dec 14, 2020Immunology

Surface-associated antigen induces B-cell permeabilization and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

F. Y. Maeda, J. J. H. van Haaren, D. B. Langley, D. Christ, N. W. Andrews, W. Song

The paper shows surface-associated antigen induces B-cell membrane permeabilization and lysosome exocytosis, enhancing antigen uptake and T-cell presentation.

bioRxiv · Jul 24, 2020Cell Biology

Phospho-tuning immunity through Denisovan, modern human, and mouse TNFAIP3 gene variants

N. W. Zammit, O. M. Siggs, P. Gray, K. Horikawa, S. R. Daley, D. B. Langley, D. Cultrone, E. K. Malle, S. N. Walters, J. E. Villanueva, J. Warren, A. Russell, M. J. Cowley, V. Gayevskiy, M. E. Dinger, , M. E. Craig

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

bioRxiv · Mar 27, 2019 · PreprintImmunology