BNIP3-mTOR Signaling Mediates Resistance to MET Inhibition in Glioblastoma
Yunzhan Li, Hanif Khan, Şeyma Demirsoy, William Bernhardt, Hannah Valensi, Jeongwu Lee, Mitchell X. Machtay, Dawit Gebremichael Aregawi, M. J. Glantz, Pierre Giglio, Shengyu Yang, Todd D. Schell, Vonn Walter, Yasin Uzun, Inan Olmez
This study identifies the BNIP3-mTOR signaling axis as a mediator of resistance to MET inhibition in glioblastoma and shows that combined MET and mTOR inhibition synergistically enhances anti-tumor effects.
bioRxiv · Dec 29, 2025 · PreprintCancer Biology