Author

M. J. Kelly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Ecology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Guo· 1 shared A. Wei· 1 shared B. A. Toth· 1 shared B. T. Kile· 1 shared C. J. Kearney· 1 shared D. Akpinaroglu· 1 shared D. D. De Carvalho· 1 shared D. McNitt· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBioengineering

A. Guo

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Author profile →

4 papers

Recent·Most cited

Structure-conditioned masked language models for protein sequence design generalize beyond the native sequence space

D. Akpinaroglu, K. Seki, A. Guo, E. Zhu, M. J. Kelly, T. Kortemme

This paper introduces Frame2seq, a structure-conditioned masked language model for protein sequence design that generates novel, stable proteins with low sequence identity to native sequences.

bioRxiv · Dec 15, 2023 · PreprintBioengineering

Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice

K. Saito, J. E. Dickey, S. R. Rodeghiero, B. A. Toth, M. J. Kelly, Y. Deng, U. Singh, G. Deng, J. Jiang, H. Cui

This study identifies a novel long ERα isoform enriched in female reproductive tissues and shows its critical role in reproductive function in female mice.

bioRxiv · Mar 22, 2022Physiology

Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

J. Salmon, I. Todorovski, S. J. Vervoort, K. L. Stanley, C. J. Kearney, L. Martelotto, F. Rossello, T. Semple, G. Mir Arnau, M. Zethoven, M. Bots, E. Vidacs, K. McArthur, E. Gressier, N. De Weerd, , R. W. Johnstone

The paper shows that inhibiting HDACs in AML promotes type I IFN production by pDCs, enhancing anti-tumor immunity and therapeutic benefit.

bioRxiv · Aug 23, 2020 · PreprintCancer Biology

Space use and resource selection of bobcats in the Appalachian Mountains of western Virginia

D. McNitt, R. S. Alonso, M. J. Cherry, M. L. Fies, M. J. Kelly

This study examines bobcat space use and resource selection in western Virginia, finding sex differences in movement and habitat preferences across seasons.

bioRxiv · Nov 5, 2019Ecology